Probing the depths of degradation: matrix metalloproteinase-2 and endometrial menstrual breakdown.

Probing the depths of degradation: matrix metalloproteinase-2 and endometrial menstrual breakdown.

Expression of Matrix Metalloproteinase-2 and -9 in Meningioma

Background: Meningioma is one of the most common tumors of the central nervous system. It was shown that meningioma had up-regulated expression of Matrix Metalloproteinases (MMPs) that involved in cell growth, angiogenesis and metastasis.  Objectives: The aim of the study was the assessment of serum MMP-2 and -9 levels in patients with different grades of meningioma.  Materials & Me...

Menstrual-like breakdown and apoptosis in human endometrial explants.

BACKGROUND Apoptosis occurs in late secretory and menstrual human endometrium and is thought to play an important role in endometrial physiology. Menstrual-like breakdown has been observed in vitro in endometrial explants. The purpose of this study was to assess the role of apoptosis in menstrual-like breakdown in human endometrial explants. METHODS Human endometrial tissue was obtained durin...

Human endometrial matrix metalloproteinase-2, a putative menstrual proteinase. Hormonal regulation in cultured stromal cells and messenger RNA expression during the menstrual cycle.

Proteinases are likely effectors of endometrial menstrual breakdown. We have investigated proteinase production by human endometrial stromal cells subjected in vitro to progesterone (P) withdrawal, the physiologic stimulus for menstruation. Culture media of cells exposed to estradiol, P, or estradiol plus P had low levels of proteolytic activity similar to cultures maintained in the absence of ...

Probing the depths

W scientists from HMS Challenger dredged animals from over 5km depth, they finally laid to rest the azoic hypothesis of Edward Forbes, that life could not exist in cold dark depths of the ocean, and thereby opened the doors to true deep-sea biology. The past decade has witnessed a further sea change in our view of marine diversity, if I may be permitted the pun, a change driven to a large exten...